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CHAC1 overexpression in human gastric parietal cells with Helicobacter pylori infection in the secretory canaliculi

Ogawa, Tomohisa; Wada, Yuriko; Takemura, Kosuke; Board, Philip; Uchida, Keisuke; Kitagaki, Keisuke; Tamura, Tomoki; Suzuki, Takashige; Tokairin, Yutaka; Nakajima, Yasuaki; Eishi, Yoshinobu


Background Cation transport regulator 1 (CHAC1), a newly discovered enzyme that degrades glutathione, is induced in Helicobacter pylori (H. pylori)‐infected gastric epithelial cells in culture. The CHAC1‐induced decrease in glutathione leads to an accumulation of reactive oxygen species and somatic mutations in TP53. We evaluated the possible correlation between H. pylori infection and CHAC1 expression in human gastric mucosa. Materials and Methods Both fresh‐frozen and formalin‐fixed...[Show more]

CollectionsANU Research Publications
Date published: 2019-05-20
Type: Journal article
Source: Helicobacter (Oxford)
DOI: 10.1111/hel.12598
Access Rights: Open Access


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