Molecular analysis of the ZIC3 and TCF7L1 interaction and its implication in human Heterotaxy
Heterotaxy is a congenital disorder that occurs due to the defective establishment of the left-right (L-R) body axis during early embryo development. The disorder affects 1/10,000 live births, results in the abnormal alignment of internal organs with respect to the L-R axis, and is often accompanied by severe cardiac malformations. The most commonly mutated gene in human cases of Heterotaxy is the X-linked ZIC3, which was first associated with the condition in 1997. ZIC3 belongs to a family of...[Show more]
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