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Novel Stenotic Microchannels to Study Thrombus Formation in Shear Gradients: Influence of Shear Forces and Human Platelet-Related Factors

Lui, Mathew; Gardiner, Elizabeth; Arthur, Jane F; Pinar, I; Lee, Woei Ming (Steve); Ryan, K; Carberry, Josie; Andrews, Robert


Thrombus formation in hemostasis or thrombotic disease is initiated by the rapid adhesion, activation, and aggregation of circulating platelets in flowing blood. At arterial or pathological shear rates, for example due to vascular stenosis or circulatory support devices, platelets may be exposed to highly pulsatile blood flow, while even under constant flow platelets are exposed to pulsation due to thrombus growth or changes in vessel geometry. The aim of this study is to investigate platelet...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: International Journal of Molecular Sciences
DOI: 10.3390/ijms20122967
Access Rights: Open Access


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