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Exploiting Drug-Apolipoprotein E Gene Interactions in Hypertension to Preserve Cognitive Function: The 3-City Cohort Study

Tully, Phillip J.; Helmer, Catherine; Peters, Ruth; Tzourio, Christophe


OBJECTIVES: The objective was to test the hypothesis that antihypertensive drugs have a differential effect on cognition in carriers and noncarriers of the apolipoprotein ε4 (APOE4) polymorphism. DESIGN: Prospective population-based cohort, France. Setting and participants: A total of 3359 persons using antihypertensive drugs (median age 74 years, 62% women) were serially assessed up to 10 years follow-up. Measures: Exposure to antihypertensive drug use was established in the first 2...[Show more]

CollectionsANU Research Publications
Date published: 2019-02-01
Type: Journal article
Source: Journal of the American Medical Directors Association
DOI: 10.1016/j.jamda.2018.08.002


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