Psoralen-loaded lipid-polymer hybrid nanoparticles enhance doxorubicin efficacy in multidrug-resistant HepG2 cells
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Yuan, Yueling; Cai, Tiange; Callaghan, Richard; Li, Qianwen; Huang, Yinghong; Wang, Bingyue; Huang, Qingqing; Du, Manling; Ma, Qianqian; Chiba, Peter; Cai, Yu
Description
Background: Psoralen (PSO), a major active component of Psoralea corylifolia, has been shown to overcome multidrug resistance in cancer. A drug carrier comprising a lipid-monolayer shell and a biodegradable polymer core for sustained delivery and improved efficacy of drug have exhibited great potential in efficient treatment of cancers. Methods: The PSO-loaded lipid polymer hybrid nanoparticles were prepared and characterized. In vitro cytotoxicity assay, cellular uptake, cell cycle analysis,...[Show more]
Collections | ANU Research Publications |
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Date published: | 2019-03-27 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/201788 |
Source: | International journal of nanomedicine |
DOI: | 10.2147/IJN.S189924 |
Access Rights: | Open Access |
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01_Yuan_Psoralen-loaded_lipid-polymer_2019.pdf | 2.5 MB | Adobe PDF |
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