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Identification of Stromal Cells in Spleen Which Support Myelopoiesis

Lim, Hong Kiat (Don); O'Neill, Helen C.


Stromal cells in spleen organize tissue into red pulp, white pulp and marginal zone, and also interact with hematopoietic cells to regulate immune responses. This study has used phenotypic information of a previously described spleen stromal cell line called 5G3, which supports restricted hematopoiesis in vitro, to identify an equivalent stromal cell subset in vivo and to test its capacity to support hematopoiesis. Using stromal cell fractionation, phenotypic analysis, as well as cell growth...[Show more]

CollectionsANU Research Publications
Date published: 2019-01-24
Type: Journal article
Source: Frontiers in Cell and Developmental Biology
DOI: 10.3389/fcell.2019.00001
Access Rights: Open Access


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