Skip navigation
Skip navigation

Novel techniques for measuring the effect of neighbouring bases on mutation and their applications

Zhu, Yicheng

Description

Understanding factors influencing mutations can improve detection of novel mutations, the diagnostic signatures of disease-causing mutagens, and facilitate the development of more accurate models of genetic divergence. Hypermutability of CpG demonstrates the existence of mutation motifs, sequences of flanking bases that influence point mutation processes. These motifs can also be indicative of specific underlying mutation mechanisms. I developed novel log-linear models for identifying mutation...[Show more]

CollectionsOpen Access Theses
Date published: 2020
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/201728
DOI: 10.25911/5f58af958e859

Download

File Description SizeFormat Image
Y_Zhu_PhD_Thesis_of_ANU.pdfThesis Material4.42 MBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  17 November 2022/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator