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Novel techniques for measuring the effect of neighbouring bases on mutation and their applications

Zhu, Yicheng


Understanding factors influencing mutations can improve detection of novel mutations, the diagnostic signatures of disease-causing mutagens, and facilitate the development of more accurate models of genetic divergence. Hypermutability of CpG demonstrates the existence of mutation motifs, sequences of flanking bases that influence point mutation processes. These motifs can also be indicative of specific underlying mutation mechanisms. I developed novel log-linear models for identifying mutation...[Show more]

CollectionsOpen Access Theses
Date published: 2020
Type: Thesis (PhD)
DOI: 10.25911/5f58af958e859


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