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A revised biosynthetic pathway for the cofactor F-420 in prokaryotes

Bashiri, Ghader; Antoney, James; Jirgis, Ehab N. M.; Shah, Mihir V.; Ney, Blair; Copp, Janine; Stuteley, Stephanie M.; Sreebhavan, Sreevalsan; Palmer, Brian; Middleditch, Martin; Tokuriki, Nobuhiko; Greening, Chris; Scott, Colin; Baker, Edward; Jackson, Colin


Cofactor F420 plays critical roles in primary and secondary metabolism in a range of bacteria and archaea as a low-potential hydride transfer agent. It mediates a variety of important redox transformations involved in bacterial persistence, antibiotic biosynthesis, pro-drug activation and methanogenesis. However, the biosynthetic pathway for F420 has not been fully elucidated: neither the enzyme that generates the putative intermediate 2-phospho-L-lactate, nor the function of the FMN-binding...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Nature Communications
DOI: 10.1038/s41467-019-09534-x
Access Rights: Open Access


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