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Screening for hemochromatosis in asymptomatic subjects with or without a family history

Powell, L W; Dixon, J L; Ramm , G A; Purdie, D M; Lincoln, D J; Anderson, G J; Subramaniam, V N; Hewett, D G; Searle, J W; Fletcher, L M; Crawford, DH; Rodgers, Helen J; Allen, K J; Cavanaugh, Juleen; Bassett, Mark

Description

Background: Hemochromatosis in white subjects is mostly due to homozygosity for the common C282Y substitution in HFE. Although clinical symptoms are preventable by early detection of the genetic predisposition and prophylactic treatment, population screening is not currently advocated because of the discrepancy between the common mutation prevalence and apparently lower frequency of clinical disease. This study compared screening for hemochromatosis in subjects with or without a family history....[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/20161
Source: Archives of Internal Medicine
DOI: 10.1001/archinte.166.3.294

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