Inhibition of Arginase I Activity by RNA Interference Attenuates IL-13-Induced Airways Hyperresponsiveness
Yang, Ming; Rangasamy, Danny; Matthaei, Klaus; Frew, Ailsa; Zimmermann, Nives; Mahalingam, Surendran; Webb, Dianne; Tremethick, David; Thompson, Philip J; Hogan, Simon; Rosenberg, Marc E; Cowden, William; Foster, Paul S
Increased arginase I activity is associated with allergic disorders such as asthma. How arginase I contributes to and is regulated by allergic inflammatory processes remains unknown. CD4+ Th2 lymphocytes (Th2 cells) and IL-13 are two crucial immune regulators that use STAT6-dependent pathways to induce allergic airways inflammation and enhanced airways responsiveness to spasmogens (airways hyperresponsiveness (AHR)). This pathway is also used to activate arginase I in isolated cells and in...[Show more]
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