Skip navigation
Skip navigation

Inhibition of Arginase I Activity by RNA Interference Attenuates IL-13-Induced Airways Hyperresponsiveness

Yang, Ming; Rangasamy, Danny; Matthaei, Klaus; Frew, Ailsa; Zimmermann, Nives; Mahalingam, Surendran; Webb, Dianne; Tremethick, David; Thompson, Philip J; Hogan, Simon; Rosenberg, Marc E; Cowden, William; Foster, Paul S


Increased arginase I activity is associated with allergic disorders such as asthma. How arginase I contributes to and is regulated by allergic inflammatory processes remains unknown. CD4+ Th2 lymphocytes (Th2 cells) and IL-13 are two crucial immune regulators that use STAT6-dependent pathways to induce allergic airways inflammation and enhanced airways responsiveness to spasmogens (airways hyperresponsiveness (AHR)). This pathway is also used to activate arginase I in isolated cells and in...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Journal of Immunology


File Description SizeFormat Image
01_Yang_Inhibition_of_Arginase_I_2006.pdf446.16 kBAdobe PDF    Request a copy

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  23 August 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator