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The Use and Abuse of Heme in Apicomplexan Parasites

van Dooren, Giel; Kennedy, Alexander T; McFadden, Geoffrey I

Description

Significance: Heme is an essential prosthetic group for most life on Earth. It functions in numerous cellular redox reactions, including in antioxidant defenses and at several stages of the electron transport chain in prokaryotes and eukaryotic mitochondria. Heme also functions as a sensor and transport molecule for gases such as oxygen. Heme is a complex organic molecule and can only be synthesized through a multienzyme pathway from simpler precursors. Most free-living organisms synthesize...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/20115
Source: Antioxidants & redox signaling
DOI: 10.1089/ars.2012.4539

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