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Targeting of plasmid DNA-lipoplexes to cells with molecules anchored via a metal chelator-lipid

Herringson, Thomas; Patlolla, Ram; Altin, Joseph

Description

Background: The ability to deliver plasmid DNA (pDNA) to specific cells in vivo is crucial for achieving efficient targeted transfection with nonviral vectors. We previously used stealth liposomes containing the chelator lipid 3(nitrilotriacetic acid)-ditetradecylamine (NTA3-DTDA) to target delivery of antigen and cytokines to immune cells in vivo. In the present study, we utilized liposomes containing NTA3-DTDA and the ionizable aminolipid 1,2-dioleoyl-3-dimethyl-ammonium-propane (DODAP) to...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
URI: http://hdl.handle.net/1885/20032
Source: Journal of Gene Medicine
DOI: 10.1002/jgm.1394

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