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S-Glutathionyl-(chloro)hydroquinone reductases: a novel class of glutathione transferases

Xun, Luying; Belchik, Sara M; Xun, Randy; Huang, Yan; Zhou, Huina; Sanchez, Emiliano; Kang, ChulHee; Board, Philip


Sphingobium chlorophenolicum completely mineralizes PCP (pentachlorophenol). Two GSTs (glutathione transferases), PcpC and PcpF, are involved in the degradation. PcpC uses GSH to reduce TeCH (tetrachloro-p- hydroquinone) to TriCH (trichlorop-hydroquinone) and then to DiCH (dichloro-p-hydroquinone) during PCP degradation. However, oxidatively damaged PcpC produces GS-TriCH (S-glutathionyl-TriCH) and GS-DiCH (Sglutathionyl-TriCH) conjugates. PcpF converts the conjugates into TriCH and DiCH,...[Show more]

CollectionsANU Research Publications
Date published: 2010
Type: Journal article
Source: Biochemical Journal
DOI: 10.1042/BJ20091863


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