S-Glutathionyl-(chloro)hydroquinone reductases: a novel class of glutathione transferases
Sphingobium chlorophenolicum completely mineralizes PCP (pentachlorophenol). Two GSTs (glutathione transferases), PcpC and PcpF, are involved in the degradation. PcpC uses GSH to reduce TeCH (tetrachloro-p- hydroquinone) to TriCH (trichlorop-hydroquinone) and then to DiCH (dichloro-p-hydroquinone) during PCP degradation. However, oxidatively damaged PcpC produces GS-TriCH (S-glutathionyl-TriCH) and GS-DiCH (Sglutathionyl-TriCH) conjugates. PcpF converts the conjugates into TriCH and DiCH,...[Show more]
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