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Action potential generation requires a high sodium channel density in the axon initial segment

Kole, Maarten; Ilschner, Susanne DR; Kampa, Bjoern; Williams, Stephen; Ruben, Peter; Stuart, Gregory J


The axon initial segment (AIS) is a specialized region in neurons where action potentials are initiated. It is commonly assumed that this process requires a high density of voltage-gated sodium (Na+) channels. Paradoxically, the results of patch-clamp studies suggest that the Na+ channel density at the AIS is similar to that at the soma and proximal dendrites. Here we provide data obtained by antibody staining, whole-cell voltage-clamp and Na+ imaging, together with modeling, which indicate...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Nature Neuroscience
DOI: 10.1038/nn2040


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