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Decreased expression of Flightless I, a gelsolin family member and developmental regulator, in early-gestation fetal wounds improves healing

Lin, Cheng-Hung; Waters, James M; Powell, B C; Arkell, Ruth; Cowin, Allison J


Up until late in the third trimester of gestation and through to adulthood, the healing response acts more to regenerate than to repair a wound. The mechanisms underlying this ''scar-free'' healing remain unknown although the actin cytoskeleton has a major role. Flightless I (Flii), an actin-remodelling protein and essential developmental regulator, negatively affects wound repair but its effect on scar-free fetal healing is unknown. Using fetal skin explants from E17 (regenerate) and E19...[Show more]

CollectionsANU Research Publications
Date published: 2011
Type: Journal article
Source: Mammalian Genome
DOI: 10.1007/s00335-011-9320-z


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