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Altered sodium currents in auditory neurons of congenitally deaf mice

Leao, Richardson; Naves, Marcell; Leao (previously Svahn), Katarina; Walmsley, Bruce

Description

Sodium currents are essential for action potential generation and propagation in most excitable cells. Appropriate tuning of these currents can be modulated both developmentally and in response to activity. Here we use a mouse model of congenital deafness (dn/dn- asymptomatic deafness associated with hair cell degeneration) to investigate the effect of lack of activity in the expression of Na+ currents in neurons from the medial nucleus of the trapezoid body (MNTB). Patch-clamp recordings show...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/19919
Source: European Journal of Neuroscience
DOI: 10.1111/j.1460-9568.2006.04982.x

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