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Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS

Zhang, William; Herde, Michel; Mitchell, Joshua; Whitfield, Jason; Wulff, Andreas B; Vongsouthi, Vanessa; Sanchez-Romero, Immaculada; Gulakova, Polina E; Minge, daniel; Breithausen, Bjorn; Schoch, Susanne; Janovjak, Harald; Jackson, Colin; Henneberger, Christian


Fluorescent sensors are an essential part of the experimental toolbox of the life sciences, where they are used ubiquitously to visualize intra- and extracellular signaling. In the brain, optical neurotransmitter sensors can shed light on temporal and spatial aspects of signal transmission by directly observing, for instance, neurotransmitter release and spread. Here we report the development and application of the first optical sensor for the amino acid glycine, which is both an inhibitory...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Nature Chemical Biology
DOI: 10.1038/s41589-018-0108-2


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