Skip navigation
Skip navigation

Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS

Zhang, William; Herde, Michel; Mitchell, Joshua; Whitfield, Jason; Wulff, Andreas B; Vongsouthi, Vanessa; Sanchez-Romero, Immaculada; Gulakova, Polina E; Minge, daniel; Breithausen, Bjorn; Schoch, Susanne; Janovjak, Harald; Jackson, Colin; Henneberger, Christian

Description

Fluorescent sensors are an essential part of the experimental toolbox of the life sciences, where they are used ubiquitously to visualize intra- and extracellular signaling. In the brain, optical neurotransmitter sensors can shed light on temporal and spatial aspects of signal transmission by directly observing, for instance, neurotransmitter release and spread. Here we report the development and application of the first optical sensor for the amino acid glycine, which is both an inhibitory...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
URI: http://hdl.handle.net/1885/198084
Source: Nature Chemical Biology
DOI: 10.1038/s41589-018-0108-2

Download

File Description SizeFormat Image
01_Zhang_Monitoring_hippocampal_glycine_2018.pdf1.99 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator