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Synaptic Interactions in Germinal Centers

Papa, Ilenia; Garcia De Vinuesa, Maria Carola


The germinal center (GC) is a complex, highly dynamic microanatomical niche that allows the generation of high-affinity antibody-producing plasma cells and memory B cells. These cells constitute the basis of long-lived highly protective antibody responses. For affinity maturation to occur, B cells undergo multiple rounds of proliferation and mutation of the genes that encode the immunoglobulin V region followed by selection by specialized T cells called follicular helper T (TFH) cells. In order...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Frontiers in Immunology
DOI: 10.3389/fimmu.2018.01858
Access Rights: Open Access


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