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De Novo Discovery of Nonstandard Macrocyclic Peptides as Noncompetitive Inhibitors of the Zika Virus NS2B-NS3 Protease

Nitsche, Christoph; Passioura, Toby; Varava, Paul; Mahawaththa, Mithun; Leuthold, Mila M.; Klein, Christian D; Suga, Hiroaki; Otting, Gottfried


The Zika virus presents a major public health concern due to severe fetal neurological disorders associated with infections in pregnant women. In addition to vaccine development, the discovery of selective antiviral drugs is essential to combat future epidemic Zika virus outbreaks. The Zika virus NS2B-NS3 protease, which performs replication-critical cleavages of the viral polyprotein, is a promising drug target. We report the first macrocyclic peptide-based inhibitors of the NS2B-NS3 protease,...[Show more]; Open Access

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: ACS Medicinal Chemistry Letters
DOI: 10.1021/acsmedchemlett.8b00535


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