Characterization of the ATP4 ion pump in Toxoplasma gondii
Lehane, Adele; Dennis, Adelaide; Bray, Katherine; Li, Dongdi; Rajendran, Esther; McCoy, James M.; Mcarthur, Hillary; Winterberg, Markus; Rahimi, Ahmed (Farid); Tonkin, Christopher J.; Kirk, Kiaran; van Dooren, Giel
The Plasmodium falciparum ATPase PfATP4 is the target of a diverse range of antimalarial compounds, including the clinical drug candidate cipargamin. PfATP4 was originally annotated as a Ca2+ transporter, but recent evidence suggests that it is a Na+ efflux pump, extruding Na+ in exchange for H+. Here we demonstrate that ATP4 proteins belong to a clade of P-type ATPases that are restricted to apicomplexans and their closest relatives. We employed a variety of genetic and physiological...[Show more]
|Collections||ANU Research Publications|
|Source:||Journal of Biological Chemistry|
|Access Rights:||Open Access|
|01_Lehane_Characterization_of_the_ATP4_2019.pdf||2.28 MB||Adobe PDF|
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