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Optimizing poly (ADP‐ribose) polymerase inhibition through combined epigenetic and immunotherapy

Prasanna, Thiru; Wu, Fan; Khanna, Kum Kum; Yip, Desmond; Malik, Laeeq; Dahlstrom, Jane; Rao, Sudha


Triple‐negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor survival outcomes. Currently, there are no targeted therapies available for TNBCs despite remarkable progress in targeted and immune‐directed therapies for other solid organ malignancies. Poly (ADP‐ribose) polymerase inhibitors (PARPi) are effective anticancer drugs that produce good initial clinical responses, especially in homologous recombination DNA repair‐deficient cancers. However, resistance is the rule...[Show more]

CollectionsANU Research Publications
Date published: 2018
Type: Journal article
Source: Cancer Science
DOI: 10.1111/cas.13799
Access Rights: Open Access


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