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Is host heparanase required for the rapid spread of heparan sulfate binding viruses?

Khanna, Mayank; Ranasinghe, Charani; Browne, Anna; Li, Jin-Ping; Vlodavsky, Israel; Parish, Christopher


Vaccinia virus (VACV), like many other viruses, binds to cell surface heparan sulfate (HS) prior to infecting cells. Since HS is ubiquitously expressed extracellularly, it seemed likely that VACV-HS interaction may impede virus spread, with host heparanase, the only known mammalian endoglycosidase that can degrade HS, potentially overcoming this problem. In support of this hypothesis, we found that, compared to wild type, mice deficient in heparanase showed a 1–3 days delay in the spread of...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Virology
DOI: 10.1016/j.virol.2019.01.001
Access Rights: Open Access


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