Khanna, Mayank; Ranasinghe, Charani; Browne, Anna; Li, Jin-Ping; Vlodavsky, Israel; Parish, Christopher
Vaccinia virus (VACV), like many other viruses, binds to cell surface heparan sulfate (HS) prior to infecting cells. Since HS is ubiquitously expressed extracellularly, it seemed likely that VACV-HS interaction may impede virus spread, with host heparanase, the only known mammalian endoglycosidase that can degrade HS, potentially overcoming this problem. In support of this hypothesis, we found that, compared to wild type, mice deficient in heparanase showed a 1–3 days delay in the spread of...[Show more]
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