Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer
Currey, Nicola; Jahan, Zeenat; Caldon, C. Elizabeth; Tran, Phuong N.; Benthani, Fahad; De Lacavalerie, Penelope; Roden, Daniel L.; Gloss, Brian S.; Campos, Claudia; Bean, Elaine; Bullman, A.; Reibe-Pal, Saskia; Dinger, Marcel; Febbraio, Mark A.; Clarke, Stephen J.; Dahlstrom, Jane; Kohonen-Corish, Maija R. J.
BACKGROUND & AIMS: The early events by which inflammation promotes cancer are still not fully defined. The MCC gene is silenced by promoter methylation in colitis-associated and sporadic colon tumors, but its functional significance in pre-cancerous lesions or polyps is not known. Here, we aimed to determine the impact of Mcc deletion on the cellular pathways and carcinogenesis associated with inflammation in the mouse proximal colon. METHODS: We generated knockout mice with deletion of Mcc in...[Show more]
|Collections||ANU Research Publications|
|Source:||Cellular and Molecular Gastroenterology and Hepatology (CMGH)|
|Access Rights:||Open Access|
|01_Currey_Mouse_Model_of_Mutated_in_2019.pdf||6.81 MB||Adobe PDF|
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