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Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer

Currey, Nicola; Jahan, Zeenat; Caldon, C. Elizabeth; Tran, Phuong N.; Benthani, Fahad; De Lacavalerie, Penelope; Roden, Daniel L.; Gloss, Brian S.; Campos, Claudia; Bean, Elaine; Bullman, A.; Reibe-Pal, Saskia; Dinger, Marcel; Febbraio, Mark A.; Clarke, Stephen J.; Dahlstrom, Jane; Kohonen-Corish, Maija R. J.


BACKGROUND & AIMS: The early events by which inflammation promotes cancer are still not fully defined. The MCC gene is silenced by promoter methylation in colitis-associated and sporadic colon tumors, but its functional significance in pre-cancerous lesions or polyps is not known. Here, we aimed to determine the impact of Mcc deletion on the cellular pathways and carcinogenesis associated with inflammation in the mouse proximal colon. METHODS: We generated knockout mice with deletion of Mcc in...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Cellular and Molecular Gastroenterology and Hepatology (CMGH)
DOI: 10.1016/j.jcmgh.2019.01.009
Access Rights: Open Access


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