Skip navigation
Skip navigation

TRP channels and a dextran sulfate activated rise in intracellular Ca2+ and Na+ in a subpopulation of double positive thymocytes

Wohlfahrt, Deborah

Description

This thesis presents the characteristics of the sustained rise of intracellular Ca2+ ([Ca2+]i) and Na+ ([Na+]i), observed in pre-selection CD4+CD8+ (double-positive, DP) thymocytes when stimulated with dextran sulfate (DxS) and explores several candidate channels that may be involved in this rise. . This [Ca2+]i rise is proposed to mimic a physiological mechanism that influences early DP thymocyte selection and hence the T cell repertoire. During thymopoiesis, the patterning of [Ca2+]i plays a...[Show more]

CollectionsOpen Access Theses
Date published: 2019
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/195780
DOI: 10.25911/5dfc9566b8992
Access Rights: Open Access

Download

File Description SizeFormat Image
Deborah Wohlfahrt Thesis 2019.pdfThesis Material7.55 MBAdobe PDFThumbnail


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator