This thesis presents the characteristics of the sustained rise of intracellular Ca2+ ([Ca2+]i) and Na+ ([Na+]i), observed in pre-selection CD4+CD8+ (double-positive, DP) thymocytes when stimulated with dextran sulfate (DxS) and explores several candidate channels that may be involved in this rise. . This [Ca2+]i rise is proposed to mimic a physiological mechanism that influences early DP thymocyte selection and hence the T cell repertoire. During thymopoiesis, the patterning of [Ca2+]i plays a...[Show more]
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