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A novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

Somers, Klaartje; Wen, V. W.; Middlemiss, S. M. C.; Osborne, B.; Forgham, H.; Jung, MoonSun; Karsa, Mawar; Clifton, Molly; Bongers, Angelika; Gao, Jixuan; Hannan, Katherine; Hannan, Ross


Survival rates for pediatric patients suffering from mixed lineage leukemia (MLL)-rearranged leukemia remain below 50% and more targeted, less toxic therapies are urgently needed. A screening method optimized to discover cytotoxic compounds selective for MLL-rearranged leukemia identified CCI-006 as a novel inhibitor of MLL-rearranged and CALM-AF10 translocated leukemias that share common leukemogenic pathways. CCI-006 inhibited mitochondrial respiration and induced mitochondrial membrane...[Show more]

CollectionsANU Research Publications
Date published: 2019-01-22
Type: Journal article
Source: Oncogene
DOI: 10.1038/s41388-018-0666-5
Access Rights: Open Access


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