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A Supervised Statistical Learning Approach for Accurate Legionella pneumophila Source Attribution during Outbreaks

Buultjens, Andrew H.; Chua, Kyra Y. L.; Baines, Sarah L.; Kwong, Jason; Gao, Wei; Cutcher, Zoe; Adcock, Stuart; Ballard, Susan; Schultz, Mark B.; Tomita, Takehiro; Subasinghe, Nela


Public health agencies are increasingly relying on genomics during Legionnaires' disease investigations. However, the causative bacterium (Legionella pneumophila) has an unusual population structure, with extreme temporal and spatial genome sequence conservation. Furthermore, Legionnaires' disease outbreaks can be caused by multiple L. pneumophila genotypes in a single source. These factors can confound cluster identification using standard phylogenomic methods. Here, we show that a statistical...[Show more]

CollectionsANU Research Publications
Date published: 2017-10-17
Type: Journal article
Source: Applied and Environmental Microbiology
DOI: 10.1128/AEM.01482-17


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