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Regulation of dendritic cell function and T cell priming by the fatty acid-binding protein AP2

Rolph, Michael; Young, Timothy R; Shum, Bennett O V; Gorgun, Cem Z; Smitz-Pfeiffer, Carsten; Ramshaw, Ian; Hotamisligil, Gokhan D; Mackay, Charles R


The fatty acid-binding protein (FABP) family consists of a number of conserved cytoplasmic proteins with roles in intracellular lipid transport, storage, and metabolism. Examination of a comprehensive leukocyte gene expression database revealed strong expression of the adipocyte FABP aP2 in human monocyte-derived dendritic cells (DCs). We isolated bone marrow-derived DC from aP2-deficieni mice, and showed that expression of DC cytokines including DL-12 and TNF was significantly impaired in...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Journal of Immunology


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