Identification of a DMBT1 Polymorphism Associated with Increased Breast Cancer Risk and Decreased Promoter Activity
Tchatchou, Sandrine; Riedel, Angela; Lyer, Stefan; Schmutzhard, Julia; Strobel-Freidekind, Olga; Gronert-Sum, Sabine; Mietag, Carola; D'Amato, Mauro; Schlehe, Bettina; Hemminki, Kari; Blackburn, Anneke; Sutter, Christian
According to present estimations, the unfavorable combination of alleles with low penetrance but high prevalence in the population might account for the major part of hereditary breast cancer risk. Deleted in Malignant Brain Tumors 1 (DMBT1) has been proposed as a tumor suppressor for breast cancer and other cancer types. Genomewide mapping in mice further identified Dmbt1 as a potential modulator of breast cancer risk. Here, we report the association of two frequent and linked...[Show more]
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