Degrees of chloroquine resistance in Plasmodium - Is the redox system involved?
Chloroquine (CQ) was once a very effective antimalarial drug that, at its peak, was consumed in the hundreds of millions of doses per year. The drug acts against the Plasmodium parasite during the asexual intra-erythrocytic phase of its lifecycle. Unfortunately, clinical resistance to this drug is now widespread. Questions remain about precisely how CQ kills malaria parasites, and by what means some CQ-resistant (CQR) parasites can withstand much higher concentrations of the drug than others...[Show more]
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|Source:||International Journal for Parasitology|
|01_Lehane_Degrees_of_chloroquine_2012.pdf||382.65 kB||Adobe PDF||Request a copy|
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