Skip navigation
Skip navigation

Degrees of chloroquine resistance in Plasmodium - Is the redox system involved?

Lehane, Adele; McDevitt, Christopher A; Kirk, Kiaran; Fidock, David A

Description

Chloroquine (CQ) was once a very effective antimalarial drug that, at its peak, was consumed in the hundreds of millions of doses per year. The drug acts against the Plasmodium parasite during the asexual intra-erythrocytic phase of its lifecycle. Unfortunately, clinical resistance to this drug is now widespread. Questions remain about precisely how CQ kills malaria parasites, and by what means some CQ-resistant (CQR) parasites can withstand much higher concentrations of the drug than others...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/19397
Source: International Journal for Parasitology
DOI: 10.1016/j.ijpddr.2011.11.001

Download

File Description SizeFormat Image
01_Lehane_Degrees_of_chloroquine_2012.pdf382.65 kBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  27 November 2018/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator