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Exploiting 4-1BB costimulation for enhancing antiviral vaccination

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Harrison, Jodie; Bertram, Edward; Ramshaw, Ian

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4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily, is emerging as an important costimulatory molecule, particularly in the regulation of CD8+ T cell responses. Costimulation through 4-1BB, such as by utilizing agonistic anti-4-1BB monoclonal antibodies, has been well studied in various tumor models. However, 4-1BB is also an important regulator of antiviral CD8+ T cell responses. This review summarizes these findings and describes how 4-1BB is beginning to be exploited in...[Show more]

dc.contributor.authorHarrison, Jodie
dc.contributor.authorBertram, Edward
dc.contributor.authorRamshaw, Ian
dc.date.accessioned2015-12-07T22:19:23Z
dc.identifier.issn0882-8245
dc.identifier.urihttp://hdl.handle.net/1885/19315
dc.description.abstract4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily, is emerging as an important costimulatory molecule, particularly in the regulation of CD8+ T cell responses. Costimulation through 4-1BB, such as by utilizing agonistic anti-4-1BB monoclonal antibodies, has been well studied in various tumor models. However, 4-1BB is also an important regulator of antiviral CD8+ T cell responses. This review summarizes these findings and describes how 4-1BB is beginning to be exploited in terms of boosting antiviral vaccine responses.
dc.publisherMary Ann Liebert Inc.
dc.sourceViral Immunology
dc.subjectKeywords: CD137 antigen; CD28 antigen; monoclonal antibody; tumor necrosis factor receptor; virus vaccine; antibody response; CD4+ T lymphocyte; CD8+ T lymphocyte; cytokine production; human; immunoregulation; innate immunity; lymphocyte proliferation; nonhuman; pr
dc.titleExploiting 4-1BB costimulation for enhancing antiviral vaccination
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume19
dc.date.issued2006
local.identifier.absfor110704 - Cellular Immunology
local.identifier.ariespublicationu6800332xPUB7
local.type.statusPublished Version
local.contributor.affiliationHarrison, Jodie, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationBertram, Edward, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationRamshaw, Ian, College of Medicine, Biology and Environment, ANU
local.bibliographicCitation.issue4
local.bibliographicCitation.startpage593
local.bibliographicCitation.lastpage601
local.identifier.doi10.1089/vim.2006.0054
dc.date.updated2015-12-07T08:34:44Z
local.identifier.scopusID2-s2.0-33846083149
CollectionsANU Research Publications

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