Skip navigation
Skip navigation

Exploiting 4-1BB costimulation for enhancing antiviral vaccination

Harrison, Jodie; Bertram, Edward; Ramshaw, Ian


4-1BB, a member of the tumor necrosis factor receptor (TNFR) superfamily, is emerging as an important costimulatory molecule, particularly in the regulation of CD8+ T cell responses. Costimulation through 4-1BB, such as by utilizing agonistic anti-4-1BB monoclonal antibodies, has been well studied in various tumor models. However, 4-1BB is also an important regulator of antiviral CD8+ T cell responses. This review summarizes these findings and describes how 4-1BB is beginning to be exploited in...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Viral Immunology
DOI: 10.1089/vim.2006.0054


There are no files associated with this item.

Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  17 November 2022/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator