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Heritable DNA methylation marks associated with susceptibility to breast cancer

Joo, Jihoon; Dowty, James; Milne, Roger; Ming Wong, E.; Dugue, Pierre-Antoine; Sexton, Adrienne; Christian, Alice; Trainer, Alison; Shelling, Andrew; Blackburn, Anneke; Fazio, Anna De; English, Dallas R.; Lindeman, Geoffrey J.; Campbell, Ian G.; Hickie, Ian B.; Tucker, Katherine M.; Jenkins, Mark A.


Mendelian-like inheritance of germline DNA methylation in cancer susceptibility genes has been previously reported. We aimed to scan the genome for heritable methylation marks associated with breast cancer susceptibility by studying 25 Australian multiple-case breast cancer families. Here we report genome-wide DNA methylation measured in 210 peripheral blood DNA samples provided by family members using the Infinium HumanMethylation450. We develop and apply a new statistical method to identify...[Show more]

CollectionsANU Research Publications
Date published: 2018-02-28
Type: Journal article
Source: Nature Communications
DOI: 10.1038/s41467-018-03058-6
Access Rights: Open Access


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