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Decreased circulating macrophage migration inhibitory factor (MIF) protein and blood mononuclear cell MIF transcripts in children with Plasmodium falciparum malaria

Awandare, Gordon A; Hittner, James B; Kremsner, Peter G; Ochiel, Daniel O; Keller, Christopher C; Weinberg, J Brice; Clark, Ian A; Perkins, Douglas J


Plasmodium falciparum malaria remains one of the most frequently lethal diseases affecting children in sub-Saharan Africa, yet the immune mediators that regulate pathogenesis are only partially defined. Since macrophage migration inhibitory factor (MIF) is important for regulating innate immunity in bacterial and parasitic infections, circulating MIF and peripheral blood mononuclear cell (PBMC) MIF transcripts were investigated in children with acute falciparum malaria. Peripheral blood levels...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Clinical Immunology
DOI: 10.1016/j.clim.2005.12.003


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