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Topographic organization in the auditory brainstem of juvenile mice is disrupted in congenital deafness

Leao, Richardson; Sun, Hong; Leao (previously Svahn), Katarina; Berntson Eichner, Amy; Youssoufian, Monique; Paolini, Antonio G; Fyffe, Robert E W; Walmsley, Bruce

Description

There is an orderly topographic arrangement of neurones within auditory brainstem nuclei based on sound frequency. Previous immunolabelling studies in the medial nucleus of the trapezoid body (MNTB) have suggested that there may be gradients of voltage-gated currents underlying this tonotopic arrangement. Here, our electrophysiological and immunolabelling results demonstrate that underlying the tonotopic organization of the MNTB is a combination of medio-lateral gradients of low-and...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
URI: http://hdl.handle.net/1885/19202
Source: Journal of Physiology
DOI: 10.1113/jphysiol.2005.098780

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