Stem cell activity in the developing human cornea
The adult cornea harbors stem cells (SCs) in its periphery, in a niche known as the limbus. Over the past 2 decades there has been substantial research into these adult corneal SCs, their limbal niche, and their therapeutic applications. However, few studies have investigated how this niche and its SCs develop in humans. To better characterize this development, human fetal corneas from 8.5-to 22-weeks'-gestation (n = 173), neonatal (n = 2), and adult (n = 10) specimens were obtained....[Show more]
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