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Amantadine inhibits the function of an ion channel encoded by GB virus B, but fails to inhibit virus replication

Premkumar, Anita; Dong, Xuebin; Haqshenas, Gholamreza; Gage, Peter; Gowans, Eric J


A chemically synthesized peptide representing the C-terminal subunit (p13-C) of the p13 protein of GB virus B (GBV-B), the most closely related virus to hepatitis C virus (HCV) showed ion channel activity in artificial lipid bilayers. The channels had a variable conductance and were more permeable to potassium ions than to chloride ions. Amantadine but not hexamethylene amiloride (HMA) inhibited the ion channel function of p13-C in the lipid membranes. However, neither agent was able to inhibit...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Antiviral Therapy


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