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PfCRT and its role in antimalarial drug resistance

Ecker, Andrea; Lehane, Adele; Clain, Jerome; Fidock, David A

Description

Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial drug, is mediated primarily by mutant forms of the chloroquine resistance transporter (PfCRT). These mutations impart upon PfCRT the ability to efflux chloroquine from

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/19146
Source: Trends in Parasitology
DOI: 10.1016/j.pt.2012.08.002

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