Synthesis of (±)-panduratin A and related natural products using the high pressure Diels-Alder reaction
Under pressure: PanduratinA (1) has been synthesized in six steps including a high pressure Diels-Alder reaction. This divergent sequence also allowed the synthesis of 4-hydroxypanduratinA, panduratinH, panduratinI, nicolaioidesinB, and 2-hydroxyisopanduratinA. The binding of panduratinA to the dengue virus NS2B-NS3 protease was investigated by NMR spectroscopy.
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|Source:||Asian Journal of Organic Chemistry|
|01_Pasfield_Synthesis_of_(±)-panduratin_A_2013.pdf||274.13 kB||Adobe PDF||Request a copy|
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