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Synthesis of (±)-panduratin A and related natural products using the high pressure Diels-Alder reaction

Pasfield, Luke; de la Cruz, Laura; Ho, Junming; Coote, Michelle; Otting, Gottfried; McLeod, Malcolm


Under pressure: PanduratinA (1) has been synthesized in six steps including a high pressure Diels-Alder reaction. This divergent sequence also allowed the synthesis of 4-hydroxypanduratinA, panduratinH, panduratinI, nicolaioidesinB, and 2-hydroxyisopanduratinA. The binding of panduratinA to the dengue virus NS2B-NS3 protease was investigated by NMR spectroscopy.

CollectionsANU Research Publications
Date published: 2013
Type: Journal article
Source: Asian Journal of Organic Chemistry
DOI: 10.1002/ajoc.201200171


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