4-1BBL coexpression enhances HIV-specific CD8 T cell memory ina poxvirus prime-boost vaccine
Harrison, Jodie; Bertram, Edward; Boyle, David B; Coupar, Barbara E H; Ranasinghe, Charani; Ramshaw, Ian
Description
We have constructed a recombinant fowlpox virus expressing HIV antigens and the costimulatory molecule 4-1BBL. When included in the boost, but not the prime of a poxvirus prime-boost strategy, 4-1BBL significantly enhanced the anti-HIV T cell response generated to this vaccination in BALB/c mice, as detected by ex vivo IFNγ ELISPOT responses, intracellular cytokine staining to HIV Gag antigens, and enumeration of Gag-reactive CD8 T cells. 4-1BBL however, is not capable of modulating the CD4 T...[Show more]
Collections | ANU Research Publications |
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Date published: | 2006 |
Type: | Journal article |
URI: | http://hdl.handle.net/1885/19053 |
Source: | Vaccine |
DOI: | 10.1016/j.vaccine.2006.06.007 |
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01_Harrison_4-1BBL_coexpression_enhances_2006.pdf | 542.37 kB | Adobe PDF | Request a copy |
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