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4-1BBL coexpression enhances HIV-specific CD8 T cell memory ina poxvirus prime-boost vaccine

Harrison, Jodie; Bertram, Edward; Boyle, David B; Coupar, Barbara E H; Ranasinghe, Charani; Ramshaw, Ian


We have constructed a recombinant fowlpox virus expressing HIV antigens and the costimulatory molecule 4-1BBL. When included in the boost, but not the prime of a poxvirus prime-boost strategy, 4-1BBL significantly enhanced the anti-HIV T cell response generated to this vaccination in BALB/c mice, as detected by ex vivo IFNγ ELISPOT responses, intracellular cytokine staining to HIV Gag antigens, and enumeration of Gag-reactive CD8 T cells. 4-1BBL however, is not capable of modulating the CD4 T...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Vaccine
DOI: 10.1016/j.vaccine.2006.06.007


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