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Distinctive Quantal Properties of Neurotransmission at Excitatory and Inhibitory Autapses Revealed Using Variance-Mean Analysis.

Bekkers, John; Ikeda, Kaori; Yanagawa, Y


Normal brain function depends on an interplay between glutamatergic and GABAergic synaptic transmission, yet questions remain about the biophysical differences between these two classes of synapse. By taking advantage of a simple culture system, we present here a detailed comparison of excitatory and inhibitory neurotransmission under identical conditions using the variance-mean (V-M) method of quantal analysis. First, we validate V-M analysis for glutamatergic autapses formed by isolated...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
Source: Journal of Neuroscience
DOI: 10.1523/JNEUROSCI.3350-08.2008


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