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Distinctive Quantal Properties of Neurotransmission at Excitatory and Inhibitory Autapses Revealed Using Variance-Mean Analysis.

Bekkers, John; Ikeda, Kaori; Yanagawa, Y

Description

Normal brain function depends on an interplay between glutamatergic and GABAergic synaptic transmission, yet questions remain about the biophysical differences between these two classes of synapse. By taking advantage of a simple culture system, we present here a detailed comparison of excitatory and inhibitory neurotransmission under identical conditions using the variance-mean (V-M) method of quantal analysis. First, we validate V-M analysis for glutamatergic autapses formed by isolated...[Show more]

CollectionsANU Research Publications
Date published: 2008
Type: Journal article
URI: http://hdl.handle.net/1885/18989
Source: Journal of Neuroscience
DOI: 10.1523/JNEUROSCI.3350-08.2008

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