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IL-3, IL-5, and GM-CSF Signaling: Crystal Structure of the Human Beta-Common Receptor

Murphy, James; Young, Ian


The cytokines, interleukin-3 (IL-3), interleukin-5 (IL-5), and granulocyte-macrophage colony stimulating factor (GM-CSF), are polypeptide growth factors that exhibit overlapping activities in the regulation of hematopoietic cells. They appear to be primarily involved in inducible hematopoiesis in response to infections and are involved in the pathogenesis of allergic and inflammatory diseases and possibly in leukemia. The X-ray structure of the beta common (βc) receptor ectodomain has given new...[Show more]

CollectionsANU Research Publications
Date published: 2006
Type: Journal article
Source: Vitamins and Hormones
DOI: 10.1016/S0083-6729(06)74001-8


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