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Metabolism, Compartmentation, Transport and Production of Acetate in the Cortical Brain Tissue Slice

Rae, Caroline; Fekete, Aurelie. D; Kashem, M. A; Nasrallah, F. A; Broer, Stefan

Description

Acetate is a two carbon intermediate in metabolism. It is an accepted marker of astrocytic metabolism, and a substrate for production of metabolites such as glutamine, glutamate and GABA. However, anomalies exist in the current explanations of compartmentation and metabolism of acetate. Here, we investigated these anomalies by examining transport, production and metabolism of acetate. Acetate is a good substrate for the neuronal monocarboxylate transporter MCT2 (KM = 2.58 ± 0.8) and the glial...[Show more]

CollectionsANU Research Publications
Date published: 2012
Type: Journal article
URI: http://hdl.handle.net/1885/18877
Source: Neurochemical Research
DOI: 10.1007/s11064-012-0847-5

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