Metabolism, Compartmentation, Transport and Production of Acetate in the Cortical Brain Tissue Slice
Acetate is a two carbon intermediate in metabolism. It is an accepted marker of astrocytic metabolism, and a substrate for production of metabolites such as glutamine, glutamate and GABA. However, anomalies exist in the current explanations of compartmentation and metabolism of acetate. Here, we investigated these anomalies by examining transport, production and metabolism of acetate. Acetate is a good substrate for the neuronal monocarboxylate transporter MCT2 (KM = 2.58 ± 0.8) and the glial...[Show more]
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