Skip navigation
Skip navigation
Open Research will be down for maintenance between 8:00 and 8:15 am on Tuesday, December 1 2020.

Early Hereditary Diffuse Gastric Cancer (eHDGC) is Characterized by Subtle Genomic Instability and Active DNA Damage Response

Nasri, Soroush; Humara, Bostjan; Anjomshoaa, Ahmad; Moradi, Nourodin; Gholipour, Naghmeh; Mashjoor, Sakineh; Zhang, Peng

Description

Diffuse gastric cancer (DGC) is one of the two primary types of stomach cancer. Carriers of germline mutations in the gene encoding E-cadherin are predisposed to DGC. The primary aim of the present study was to determine if genomic instability is an early event in DGC and how it may lead to disease progression. Chromosomal aberrations in early intramucosal hereditary diffuse gastric cancer (eHDGC) were assessed using array comparative genomic hybridization (array CGH). Notably, no aneuploidy or...[Show more]

CollectionsANU Research Publications
Date published: 2018-12-13
Type: Journal article
URI: http://hdl.handle.net/1885/188611
Source: Pathology and Oncology Research
DOI: 10.1007/s12253-018-0547-9

Download

File Description SizeFormat Image
01_Nasri_Early_Hereditary_Diffuse_2019.pdf1.19 MBAdobe PDF    Request a copy


Items in Open Research are protected by copyright, with all rights reserved, unless otherwise indicated.

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator