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Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation

Diesch, Jeannine; Bywater, Megan J.; Sanij, Elaine; Cameron, Donald; Schierding, W.; Brajanovski, Natalie; Son, Jinbae; Sornkom, Jirawas; Hein, Nadine; Evers, Maurits; Pearson, Rick; McArthur, Grant; Ganley, Austen; O'Sullivan, J. M.; Qureshi, Hannan; Poortinga, Gretchen


The three-dimensional organization of the genome contributes to its maintenance and regulation. While chromosomal regions associate with nucleolar ribosomal RNA genes (rDNA), the biological significance of rDNA-genome interactions and whether they are dynamically regulated during disease remain unclear. rDNA chromatin exists in multiple inactive and active states and their transition is regulated by the RNA polymerase I transcription factor UBTF. Here, using a MYC-driven lymphoma model, we...[Show more]

CollectionsANU Research Publications
Date published: 2019-01-28
Type: Journal article
Source: Communications Biology
DOI: 10.1038/s42003-019-0284-y
Access Rights: Open Access


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