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Haematopoietic stem cells in spleen have distinct differentiative potential for antigen presenting cells

Tan, Jonathan; O'Neill, Helen


Dendritic cells (DC) are known to develop from macrophage dendritic progenitors (MDP) in bone marrow (BM), which give rise to conventional (c)DC and monocytes, both dominant antigen presenting cell (APC) subsets in spleen. This laboratory has however defined a distinct dendritic-like cell subset in spleen (L-DC), which can also be derived in long-term cultures of spleen. In line with the restricted in vitro development of only L-DC in these stromal cultures, we questioned whether self-renewing...[Show more]

CollectionsANU Research Publications
Date published: 2009
Type: Journal article
Source: Journal of Cellular and Molecular Medicine
DOI: 10.1111/j.1582-4934.2009.00923.x


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