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Of HIT, Scissors and Rocks - Mechanistic basis of GPVI shedding in heparin-induced thrombocytopenia

Lee, Christine

Description

The most famous role for platelets is in thrombosis and haemostasis. Glycoprotein (GP) VI is a platelet-specific collagen and fibrin receptor which controls thrombus formation and growth. Human GPVI is stable on resting platelets but is rapidly metalloproteolysed by A-Disintegrin-And-Metalloproteinase (ADAM) 10 on activated platelets to release soluble GPVI (sGPVI). Regulation of platelet ADAM10 metalloproteolytic activity remains unclear. Active ADAM10 are detectable on resting human platelets...[Show more]

CollectionsOpen Access Theses
Date published: 2019
Type: Thesis (PhD)
URI: http://hdl.handle.net/1885/187245
DOI: 10.25911/5f58b07f58ea7

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