Of HIT, Scissors and Rocks - Mechanistic basis of GPVI shedding in heparin-induced thrombocytopenia
The most famous role for platelets is in thrombosis and haemostasis. Glycoprotein (GP) VI is a platelet-specific collagen and fibrin receptor which controls thrombus formation and growth. Human GPVI is stable on resting platelets but is rapidly metalloproteolysed by A-Disintegrin-And-Metalloproteinase (ADAM) 10 on activated platelets to release soluble GPVI (sGPVI). Regulation of platelet ADAM10 metalloproteolytic activity remains unclear. Active ADAM10 are detectable on resting human platelets...[Show more]
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|Revised PhD Thesis Christine LEE December 2019.pdf||Thesis Material||7.59 MB||Adobe PDF|
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