Skip navigation
Skip navigation

Is protein structure enough? A review of the role of lipids in SLC6 transporter function

Schumann-Gillett, Alexandra; Blyth, Mitchell; O'Mara, Megan

Description

SLC6 neurotransmitter transporters facilitate the Na+- and Cl−-dependent uptake of amino acids and amino acid derivatives into cells. Disrupting transport leads to a range of neurological disorders. However, the SLC6 substrate transport mechanism is a topic of ongoing debate. Here, we review the prominent SLC6 substrate transport mechanisms through the lens of molecular dynamics simulations. SLC6 transporters are membrane proteins, yet their transport mechanism(s) have largely been studied...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
URI: http://hdl.handle.net/1885/187136
Source: Neuroscience Letters
DOI: 10.1016/j.neulet.2018.05.020
Access Rights: Open Access

Download

File Description SizeFormat Image
NSL-172126R2_accepted.pdf380.43 kBAdobe PDFThumbnail


This item is licensed under a Creative Commons License Creative Commons

Updated:  19 May 2020/ Responsible Officer:  University Librarian/ Page Contact:  Library Systems & Web Coordinator