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Is protein structure enough? A review of the role of lipids in SLC6 transporter function

Schumann-Gillett, Alexandra; Blyth, Mitchell; O'Mara, Megan


SLC6 neurotransmitter transporters facilitate the Na+- and Cl−-dependent uptake of amino acids and amino acid derivatives into cells. Disrupting transport leads to a range of neurological disorders. However, the SLC6 substrate transport mechanism is a topic of ongoing debate. Here, we review the prominent SLC6 substrate transport mechanisms through the lens of molecular dynamics simulations. SLC6 transporters are membrane proteins, yet their transport mechanism(s) have largely been studied...[Show more]

CollectionsANU Research Publications
Date published: 2019
Type: Journal article
Source: Neuroscience Letters
DOI: 10.1016/j.neulet.2018.05.020
Access Rights: Open Access


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