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Phylogenetic and biochemical evidence for sterol synthesis in the bacterium Gemmata obscuriglobus

Pearson, Ann; Budin, Meytal; Brocks, Jochen


Sterol biosynthesis is viewed primarily as a eukaryotic process, and the frequency of its occurrence in bacteria has long been a subject of controversy. Two enzymes, squalene monooxygenase and oxidosqualene cyclase, are the minimum necessary for initial biosynthesis of sterols from squalene. In this work, 19 protein gene sequences for eukaryotic squalene monooxygenase and 12 protein gene sequences for eukaryotic oxidosqualene cyclase were compared with all available complete and partial...[Show more]

CollectionsANU Research Publications
Date published: 2003
Type: Journal article
Source: PNAS - Proceedings of the National Academy of Sciences of the United States of America
DOI: 10.1073/pnas.2536559100


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