Shaw, Marnie; Sachdev, Perminder Singh; Abhayaratna, Walter; Anstey, Kaarin; Cherbuin, Nicolas
Objective: High BMI at midlife is associated with increased risk of dementia as well as faster decline in cognitive function. In late-life, however, high BMI has been found to be associated with both increased and decreased dementia risk. The objective of this study was to investigate the neural substrates of this age-related change in body mass index (BMI) risk. Methods: We measured longitudinal cortical thinning over the whole brain, based on magnetic resonance imaging scans for 910...[Show more]
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