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Species Variability in Cardiovascular Research: The Example of Adrenocorticotrophin-Induced Hypertension

Whitworth, Judith; Zhang, Yi; Mangos, George; Kelly, John J

Description

1. Lawrie Beilin has contributed greatly to international hypertension research through both animal and human studies. 2. Animals are used in biomedical research to gain insights that can be extrapolated ultimately to humans. 3. A simple experimental manipulation, adrenocorticotrophin (ACTH) administration, has a range of different cardiovascular effects in different species. 4. Caution should be exercised in extrapolating data from animals to humans.

dc.contributor.authorWhitworth, Judith
dc.contributor.authorZhang, Yi
dc.contributor.authorMangos, George
dc.contributor.authorKelly, John J
dc.date.accessioned2015-12-07T22:17:24Z
dc.identifier.issn0305-1870
dc.identifier.urihttp://hdl.handle.net/1885/18537
dc.description.abstract1. Lawrie Beilin has contributed greatly to international hypertension research through both animal and human studies. 2. Animals are used in biomedical research to gain insights that can be extrapolated ultimately to humans. 3. A simple experimental manipulation, adrenocorticotrophin (ACTH) administration, has a range of different cardiovascular effects in different species. 4. Caution should be exercised in extrapolating data from animals to humans.
dc.publisherBlackwell Science Asia
dc.sourceClinical and Experimental Pharmacology and Physiology
dc.subjectKeywords: arginine; atenolol; beta adrenergic receptor blocking agent; corticotropin; minoxidil; nisoldipine; nitric oxide; ramipril; tetracosactide; tetracosactide zinc phosphate; blood pressure; cardiovascular effect; conference paper; human; hypertension; kidney Blood pressure; Dog; Humans; Mouse; Rat; Sheep; Steroids
dc.titleSpecies Variability in Cardiovascular Research: The Example of Adrenocorticotrophin-Induced Hypertension
dc.typeJournal article
local.description.notesImported from ARIES
local.identifier.citationvolume33
dc.date.issued2006
local.identifier.absfor110201 - Cardiology (incl. Cardiovascular Diseases)
local.identifier.ariespublicationu9505948xPUB4
local.type.statusPublished Version
local.contributor.affiliationWhitworth, Judith, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationZhang, Yi, College of Medicine, Biology and Environment, ANU
local.contributor.affiliationMangos, George, University of New South Wales
local.contributor.affiliationKelly, John J, University of New South Wales
local.bibliographicCitation.startpage887
local.bibliographicCitation.lastpage891
local.identifier.doi10.1111/j.1440-1681.2006.04460.x
dc.date.updated2015-12-07T08:06:43Z
local.identifier.scopusID2-s2.0-33747051730
CollectionsANU Research Publications

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